Eukaryotic Gene Expression

Let’s discuss gene expression, using the human beta-globin (HBB) gene as an example. Recall that beta-globin is one of the polypeptide subunits of hemoglobin, the protein that carries oxygen in red blood cells. Some additional information can be found in your Molecular Genetics lab and here: https://ghr.nlm.nih.gov/gene/HBB# Imagine that you are a wild-type (HbA) allele of the HBB gene located on human chromosome 11. Writing from the first person perspective, how is the beta-globin polypeptide produced from your gene? In your response, be sure to describe the three main processes involved in eukaryotic gene expression: transcription, RNA processing, and translation. Conclude by discussing the mutation in the beta-globin gene that results in sickle cell anemia.

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