Applied science

This case-study examines the patterns, symmetries, associations and causality in a rare but devastating disease, amyotrophic lateral sclerosis (ALS). A major clinically relevant question in this biomedical study is: What patient phenotypes can be automatically and reliably identified and used to predict the change of the ALSFRS slope over time?. This problem aims to explore the data set by unsupervised learning.Load and prepare the data.Perform summary and preliminary visualization.Train a k-Means model on the data, experiment at least two different k values, and explain which k value is a better choice.Evaluating the model performance by report the center of clusters.Visualize the final clustering result.Submit Python code, report that explains the k experiment, performance evaluation, and visualizations.

Write a short paper discussing the application of this course to your work environment. Address the questions listed below in your paper:How will you apply the skills acquired from this course to your job?How will this course assist you in your professional or/and academic development?If the skills acquired in this course will not directly apply to your job environment, in what other ways are you hoping to apply them to your personal or academic portfolio?Your research paper should be at least 1 page (Minimum 250 words) , double-spaced, have at least 2 APA references, and typed in an easy-to-read font in MS Word (other word processors are fine to use but save it in MS Word format) . Your cover page should contain the following: Title, Student’s name, University’s name, Course name, Course number, Professor’s name, and Date.APA citation format is required.Submit your assignment on or before the due date.

This is a required assignment worth 75 points (75-points/1000-points). Assignment must be submitted by the due date. No late assignments are allowed. Please discuss the following topics and provide substantive comments to at least two other posts. Select from the following list one topic and discuss. Your submission must be 400 words and be in APA format.The discussion questions this week are from Chapter’s 16-20 (Jamsa, 2013).Chapter 16 topics:Define and describe total cost of ownership. List at least 10 items to consider when determining a data center’s total cost of ownership.Define and describe a capital expense. How are capital expenses different from operational expenses?Define and describe economies of scale and provide a cloud-based example.Define and describe “right sizing” as it pertains to cloud computing.Define Moore’s law and discus how it might influence cloud migration.Given company revenues of $2.5 million and expenses of $2.1 million, calculate the company’s profit and profit margin.Chapter 17 topics:Compare and contrast functional and nonfunctional requirements and provide an example of each.Discuss why a designer should avoid selecting an implementation platform for as long as possible during the design process.Discuss various trade-offs a designer may need to make with respect to nonfunctional requirements.Discuss why the system maintenance phase is often the most expensive phase of the software development life cycle.Chapter 18 topics:Using Yahoo! Pipes, create a pipe that displays the names of pizza restaurants within a given zip code.Using Google App Engine, create a page that displays the following Python script:print “Content-type: text/htmlnn”print “Cloud Computing, Chapter 18“Chapter 19 topics:Define scalability.List five to ten potential relationships that align with the Pareto principle, such as how 80 percent of sales come from 20 percent of customers.Compare and contrast vertical and horizontal scaling.Explain the importance of the database read/write ratio.Assume a site guarantees 99.99 percent uptime. How many minutes per year can the site be down?Chapter 20 topics:List and describe five ways you think the cloud will change the future of TV.List and describe five potential uses for intelligent fabric.List and describe five ways the cloud will influence the mobile application market, or vice versa.Discuss the importance of HTML 5.Discuss how the cloud will impact future operating systems.List and describe three potential location-aware applications.List and describe five ways intelligent devices may work together.Supplementary topic:Discuss the importance and function of a Content Delivery Network

1. Composition deals with the overall readability and meaning of the project. As noted by Kirk (2016), the topic of composition is divided into project-level and chart-level composition. Select one component of either project composition or chart composition and discuss.2. We have spent the past weeks working on the individual visualization layers and last week we learned how the layers all fit together. This week we will concentrate on creating visualizations (write) and consuming visualizations (read) (Kirk, 2016). We must first learn how to understand the visualization as viewer and at the same time use our skills, knowledge and mindsets to achieve excellence in data visualization design. We will focus on “The Seven Hats of Data Visualization.” Select one of the “Hats” and expand it for your classmates.

Write a 1,250-1,500 word paper in which you explore decision-making methods that can be used to resolve an ethical dilemma using the scenario provided in the assigned reading, “An Unconscious Patient With a DNR Tattoo.” Describe how to use the principles of ethical decision making (reviewed in this topic) to help resolve this ethical dilemma. Address the scenario to generate your conclusions about how you would proceed.What are the dimensions of the ethical dilemma?What are the potential organizational policies to which you will refer?Analyze the situation using one of the ethical theories discussed in the textbook. Describe how one might formulate assistance to the clinical staff using this theory.Describe the importance of reasoning in the decision-making process.Considering this dilemma, describe how a Christian worldview would inform ethical responsibilities?Prepare this assignment according to the guidelines found in the APA Style Guide, located in the Student Success Center. An abstract is not required.This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion.You are required to submit this assignment to LopesWrite. Refer to the LopesWrite Technical Support articles for assistance.

Scenario:Most healthcare organizations in the country are implementing quality improvement programs to save lives, enhance customer satisfaction, and reduce the cost of healthcare services. Limited human and material resources often undermine such efforts. Zenith Hospital in a rural community has 200 beds. Postsurgical patients tend to contract infections at the surgical site, requiring extended hospitalization. Mr. Jones—75 years old—was admitted to Zenith Hospital for inguinal hernia repairs. He was also hypertensive, with a compromised immune system. Two days after surgery, he acquired an infection at the surgical site, with elevated temperature, and then he developed septicemia. His condition worsened, and he was moved to isolation in the intensive care unit (ICU). A day after transfer to the ICU, he went into ventricular arrhythmia and was placed on a respirator and cardiac monitoring machine. Intravenous fluids, antibiotics, and antipyretics could not bring the fever down, and blood analysis continued to deteriorate.The hospital infection control unit got involved. The team confirmed that postsurgical infections were on the increase, but the hospital was unable to identify the sources of infection. The surgery unit and surgical team held meetings to understand possible sources of infection. The team leader had earlier reported to management that they needed to hire more surgical nurses, arguing that nurses in the unit were overworked, had to go on leave, and often worked long hours without break.Mr. Jones’ family members were angry and wanted to know the source of his infection, why he was on the respirator in isolation, and why his temperature was not coming down. Unfortunately, his condition continued to deteriorate. His daughter invited the family’s legal representative to find out what was happening to her father and to commence legal proceedings.Then, the healthcare manager received information that two other patients were showing signs of postsurgical infection. The healthcare manager and care providers acknowledged the serious quality issues at Zenith Hospital, particularly in the surgical unit. The healthcare manager wrote to the Chairman of the Hospital Board, seeking approval to implement a quality improvement program. The Board held an emergency meeting and approved the manager’s request. The healthcare manager has invited you to support the organization in this process.Please address the following questions in your response:What are successful approaches for gaining a shared understanding of the problem?How can effective communication be implemented?What is a qualitative approach that helps in identifying the quality problem?What tools can provide insight into understanding the problem?In quality improvement, what does appreciative inquiry help do?What is a benefit of testing solutions before implementation?What is a challenge that is inherent in the application of the plan, do, study, act (PDSA) method?What are the attributes of the outcome measure?What are the attributes of the measurement for improvement?Why is collecting the right data important?What is a component of establishing a culture of quality improvement in healthcare organizations?What knowledge do healthcare managers require to sustain a quality culture?Submitting your assignment in APA format means, at a minimum, you will need the following:Title page: Remember the running head. The title should be in all capitals.Length: 3 pages minimumAbstract: This is a summary of your paper, not an introduction. Begin writing in third person.Body: This begins on the page following the title page and abstract page and must be double-spaced (be careful not to triple- or quadruple-space between paragraphs). The typeface should be 12-pt. Times Roman or 12-pt. Courier in regular black type. Do not use color, bold type, or italics, except as required for APA-level headings and references. The deliverable length of the body of your paper for this assignment is 5 pages. In-body academic citations to support your decisions and analysis are required. A variety of academic sources is encouraged.Reference page: References that align with your in-body academic sources are listed on the final page of your paper. The references must be in APA format using appropriate spacing, hanging indent, italics, and uppercase and lowercase usage as appropriate for the type of resource used. Remember, the Reference page is not a bibliography but a further listing of the abbreviated in-body citations used in the paper. Every referenced item must have a corresponding in-body citation.

Promoting Safety and QualityThroughout your education, patient safety and improving the quality of patient care have been examined. Through numerous readings and media pieces, you have heard about Never Events. These are serious and costly medical errors that are preventable, such as wrong-side surgery, medication errors, and hospital-acquired infections. Each of these types of medical errors is preventable. The consequences of such errors are now financial as well as legal and emotional. The Centers for Medicare & Medicaid Services no longer reimburse for medical errors classified as Never Events.In the article “Managing to Improve Quality(See article under required readings): The Relationship Between Accreditation Standards, Safety Practices, and Patient Outcomes,” the authors discuss the growing trend by medical insurance companies to eliminate reimbursement for Never Events. As these types of mistakes should be easily preventable, hospitals have developed protocols to lessen or extinguish the occurrence of these events. In addition, The Joint Commission (TJC) and the Centers for Medicare & Medicaid Services (CMS) have developed core measures to guide health care providers’ efforts in improving patient safety and the quality of care delivered.Health care organizations have developed strategic agendas to help meet these standards and reduce the incidence of Never Events. Nurses significantly influence the overall quality of health care provided and play a pivotal role in improving patient outcomes.For this Discussion, you will consider the standards that are in place for nurses and how they can be used to improve quality of care.To prepare for this Assignment:1. Review the information at the Joint Commission and Centers for Medicare & Medicaid Services websites on the core measures and standards presented in this week’s Resources.2. Consider the nurse’s role in supporting the organization’s strategic agenda as it relates to improving clinical outcomes.3. Conduct an Internet search for either a Never Event or a core measure, and select one to address in your post.Respond to the following:1.How has the emphasis on quality of care, patient safety, and clinical care outcomes been impacted by specific standards emanating from TJC and/or CMS? Cite your selected core measure or Never Event in your response.2. What is the impact of the nurse’s role in clinical outcomes for the organization?3. Discuss nurse-specific challenges in influencing change in quality improvement.4. How does this influence the ability of the organization to achieve its strategic agenda?Initial Post: At least 450 words response. Be sure to use evidence from the readings and include in-text citations. Utilize essay-level writing practice and skills, including the use of transitional material and organizational frames. Avoid quotes; paraphrase to incorporate evidence into your own writing. A reference list is required. Use the most current evidence (usually ? 5 years old). Support your response with references from the professional nursing literature.Grading Rubric1. Analyze how specific standards emanating from CMS and/or TJC have impacted quality of care, patient safety, and clinical care outcomes for a selected core measure or Never Event.2. Determined the impact of the nurse’s role in clinical outcomes for the organization3. Differentiated selected nurse specific challenges in influencing change in quality improvement.4. Considered how these challenges influence the ability of the organization to achieve its strategic agenda

Quality Analysis, Part 2For the company and product or service that you selected for the W3 Project, complete the following:Imagining yourself to be viewing the company’s product or service through the eyes of the customer, construct a House of Quality to provide the organization with your perspectives on what the important dimensions of quality are and how well the organization is currently meeting your needs.Develop a SPC checklist for each dimension of the product that you believe would be subject to statistical control.Evaluate the product using the five-step plan that is associated with the Kaizen philosophy.Propose what elements of the production and delivery of the product or service would be subject to benchmarking and how you would identify those organizations to which comparisons could be made in a benchmarking process.Submission Details:Submit your report in a three

compare and contrast use use of natural sweeteners and artificial sweeteners in food processing and preservation

The unapproved use of approved drugs, also called off-label use, with children is quite common. This is because pediatric dosage guidelines are typically unavailable, since very few drugs have been specifically researched and tested with children.Explain the circumstances under which children should be prescribed drugs for off-label use. Be specific and provide examples.Describe strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. Include descriptions and names of off-label drugs that require extra care and attention when used in pediatrics.